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Preventing End Stage Kidney Failure Part 4

Posted on May 1, 2010 at 10:35 PM

A kidney contains about one million nephrons, which are the filtration systems of the body. They regulate the amount of water, salts, glucose, urea and other crucial minerals.


One of the most important measurements of kidney function is called the glomerular filtration rate (GFR). The glomerular filtration rate is commonly derived from a formula in which age, sex, race, and plasma creatinine are relevant variables. GFR above 90 milliliters per minute is normal, and below 15 denotes end stage kidney disease.


An issue of vicious cycle causation is elevated homocysteine in the blood, which not only contributes to atherosclerosis, but can bring on kidney failure. This cycle allows homocysteine to build up even higher, causing more atherosclerosis.


An unfortunate paradox of end stage kidney disease is that homocysteine lowering B-vitamins such as B6, folate and B12 can actually worsen it. Based on research conducted at five university medical centres.


The water solubility of B-vitamins is easily excretable in healthy people, however those with kidney failure may not be able to do so based on adverse effects observed in the research. Therefore, using heavy metal chelation such as OSR, should first be used until kidney health is strong enough to handle taking supplemental B-vitamins.


As the kidney improves with heavy metal chelation, the root of elevated homocysteine may stablize, and if it does successfully, the thyroid gland may also improve. The state of the thyroid is intimately involved in the regulation of homocysteine, thus treating the cause of homocysteine elevation maybe a key to success.


Conversely, limiting treatment to lowering homocysteine only, for chronic kidney disease does not improve outcome.


The kidney normally plays an important role in the metabolism, degradation, and excretion of several thyroid hormones. It is not surprising therefore that impairment in kidney function leads to disturbed thyroid physiology.


Failing kidney function results in all levels of hypothalamic-pituitary-thyroid axis faltering, including alterations in hormone production, distribution, and excretion. This means with an expectation of improvement of kidney function, hormone balance will improve accordingly.


If kidney health becomes severe, it may bring on secondary hyperparathyroidism, due to problems with the ability to break down and remove phosphate. A patient at this time may also need the active form of vitamin D, called calicitriol as it may lose the ability to synthesize vitamin D on its own.


Careful controlled doses of the active form of vitamin D or pre-formed, such as calcitriol and alfacalcidol can be administered to those with chronic kidney disease (CKD).


As mentioned earlier, atherosclerosis can bring on kidney failure. Atherosclerosis in the peripheral arteries implies atherosclerosis elsewhere, and in such places when poor circulation occurs in the kidneys, it is the hallmark of chronic kidney failure and, ultimately, end-stage kidney disease.


So while metal chelation and Benfotiamine can allow the kidneys to recover, amongst other important nutritional considerations depending upon the stage, there is another nutrient to help prevent the dreaded possibility of hemodialysis, the mechanical, man-made version of the kidney.


Despite the normal role that water soluble B-vitamins provide to lower homocysteine levels, they are of no use in end stage kidney disease, and as stated before, can make things only worse, despite lowering homocysteine levels.


The alternative is the use of propionyl-L-carnitine (PLC), which not only lowers homocysteine, it also lowers endothelin-1, which constricts the arteries. As the kidneys begin to deteriorate, they produce diminishing quantities of the amino acid, carnitine. Taking either acetyl-L-carnitine (ALC) or propionyl-L-carnitine (PLC) can help protect the kidney and are more bioavailable than regular L-carnitine.


An excellent addition to PLC or ALC carnitine is Lipoic acid. Lipoic acid is an ideal, natural compound that augments kidney protection. Lipoic acid is both water and fat soluble, therefore it is widely distributed in all tissue.


Lipoic acid scavenges hydroxyl radicals, hypochlorous acid and singlet oxygen while exerting transitional metal chelation. Vitamin C is often shunned in kidney treatments due to concerns over oxalate stones, so it is helpful that

lipoic acid "recycles" endogenous antioxidants such as Vitamin C and E.


Several clinical studies have shown lipoic acid as a therapeutic agent for such diverse conditions as diabetes, atherosclerosis, insulin resistance, neuropathy, which in part are all related to kidney function.


It is important to note that the synthetic antioxidant, Oxidative Stress Relief (OSR), should be taken at least 4-hours apart from lipoic acid.


In the next Daily Topic, will conclude some final treatment options and considerations to help prevent end stage kidney failure.


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4 Comments

Reply teaman
11:09 AM on May 5, 2010 
IH,
Please comment on the following post,
Thanks.
Public release date: 4-May-2010
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Contact: Sally Stewart
[email protected]
310-248-6566
Cedars-Sinai Medical Center

High doses of antioxidant supplements induce stem cell genetic abnormalities
LOS ANGELES (May 5, 2010) ? High doses of antioxidant nutritional supplements, such as vitamins C and E, can increase genetic abnormalities in cells, which may predispose supplement-takers to developing cancer, according to a new study from the Cedars-Sinai Heart Institute.

The study, led by Eduardo Marbán, M.D., Ph.D., director of the Cedars-Sinai Heart Institute, was published online today in the medical journal Stem Cells. The study also will appear in the journal's July printed edition.

Marbán and his team accidentally discovered the danger of excessive antioxidant doses while seeking a way to reduce the genetic abnormalities that occurred naturally when the scientists sought to multiply human cardiac stem cells.

Marbán stressed that the study's finding applies only to excessive nutritional supplements and not to foods that are rich in antioxidants, such as milk, oranges, blueberries and peanuts. In recent years, multiple studies have touted the benefits of foods rich in antioxidants.

"Taking one multivitamin daily is fine, but a lot of people take way too much because they think if a little is good, a lot must be better," said Marbán, who is also the Mark Siegel Family Professor at Cedars-Sinai. "That is just not the case. If you are taking 10 or 100 times the amount in a daily multivitamin, you may be predisposing your cells to developing cancer, therefore doing yourself more harm than good."

In laboratories, stem cells are often grown in a Petri dish culture than is composed of 20 percent oxygen, whereas cells growing inside human tissue are exposed to just 3 to 5 percent oxygen. But Marbán's team of researchers became frustrated because the higher concentration of oxygen in lab-grown stem cells resulted in 9 percent of the cells being rejected because of genetic abnormalities.

"We sought to counter that oxidation problem by adding high doses of antioxidants directly to the cells," Marbán said. "That's when we made the serendipitous discovery that there is a danger zone for the cells exposed to antioxidants to develop genetic abnormalities that predispose to cancer."

Marbán is leading an ongoing, groundbreaking clinical trial in which heart attack patients undergo two minimally-invasive procedures in an effort to repair and re-grow healthy muscle in a heart injured by a heart attack. First, a biopsy of each patient's own heart tissue is used to grow specialized heart stem cells. About a month later, the multiplied stem cells are then injected back into the patient's heart via a coronary artery.

The two-step procedure was completed on the first patient in June 2009. The results of the trial are expected in early 2011.

Recently, Marbán received a $5.5 million grant from the California Institute for Regenerative Medicine to continue developing cardiac stem cell therapies.
Reply Immortalhair
5:02 PM on May 5, 2010 
The author of that study suggested something is is not reflective of clinical reality. His opinion was derived from a labratory under different conditions outside the human body. Hopefully this story will not be reported as it was in other venues, because as it happens too often, opinion is usually more interesting than just the facts.

Incidentally, stem cells are precursors to cancer--that is to say that they be converted to cancer given the proper environment. Take note that in the experiment, they were multplying the stem cells--not exactly normal conditions in the human body.

When antioxidants such as vitamin C are used in cancer, via administration of IV, vitamin C converts to a pro-oxidant, which raises the white cell production of hydrogen peroxide, effectively kills off cancer cells.
Reply Amy Wike
1:10 PM on January 19, 2011 
Using a natural, organic multivitamin (www.focusfactor.com/bestmultivitamin) is best for these severe situations.
Reply Akezeneyoy
10:38 PM on June 7, 2017 
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