|Posted on August 27, 2009 at 8:15 PM|
If recent reports of artificial sweeteners actually increasing rates of obesity and cardiovascular disease do not have you questioning the use of Splenda or sucralose as it is also called, then there is yet another reason to avoid this ubiquitously found sweetener--it destroys beneficial intestinal microflora!
Unfortunately, the news gets worse in that the effects occurred over a protracted period, even after daily intake of Splenda was stopped.
There's no studies yet on how this affects human microflora, but in male Sprague-Dawley rats, modest amounts of Splenda were enough to
significantly deplete numbers of bifidobacteria, lactobacilli, bacteroides, clostridia, and aerobic bacteria. Splenda also increased fecal pH. It is not healthy to increase intestinal pH as it can reduce nutrient absorption and lead to increased pathogenic bacteria.
Lastly, Splenda enhanced expression levels of P-gp, CYP3A4, and CYP2D1, which are known to limit the bioavailability of orally administered drugs.
Also very troublesome is that our intestinal microflora are a primary source of acquiring vitamin K2 (menaquinones), that is because they synthesize it. Vitamin K2 does much more than help with blood clotting, as it also regulates coagulation (prevents excess clotting), inhibits arterial calcification, and connective tissue disorders. It helps with bone, hair and proper cell development by binding to Bone Morphogenic Protein-2. If there is insufficent vitamin K2 and low levels of HDL (high density lipoprotein, its primary shuttle in the vasculature), then bone morphogenic protein-2 is free to calcify tissue and the arterial system
J Toxicol Environ Health A. 2008;71(21):1415-29.